Die getrockneten Wurzel von der Pflanze Picrorrhiza kurrooa Roleex Benth.
Länge 6cm, 4 mm Durchmesser.  Dunkelbraun mit weißen Banden, schuppenartig,
verknöchert.
 

Picrorrhiza, Rhz. – HU HUANG LIAN – Asiatischer Braunwurz

Dosis: 9-16g/Tag

Der bittere Braunwurz ist ein antibakterielles und entkrampfendes Mittel bei feuchter Hitze.
Darüber hinaus regt er die Verdauungsdrüsen an und wirkt auf Hirnschleim.

1.     Kardioprotektiv

Cardioprotective effect of root extract of Picrorhiza kurroa (Royle Ex Benth) against isoproterenol-induced cardiotoxicity in rats

The results suggest that P. kurroa root extract possesses significant cardioprotective effect, which may be attributed to its antioxidant, anti-peroxidative, and myocardial preservative properties.

2. Malaria

Chemical investigation of an antimalarial Chinese medicinal herb Picrorhiza scrophulariiflora

Compound 10 inhibited the growth of the Plasmodium falciparum 3D7 malarial parasite line, with an IC50 value of 8.3μM. This compound accounted for ∼95% of P. falciparum growth inhibitory activity in the crude extract confirming, for this TCM, that a single compound was responsible for the antimalarial activity.
 

3. Colitis

Protective effect of apocynin in a mouse model of chemically-induced colitis

Treatment with apocynin and rutin ameliorated the course of colonic inflammation with results similar to those of the reference drug, as could be seen by reductions in the disease activity index scores and colon length.
 

4. Neuroprotektion

The neuroprotective effects of apocynin

In this review, we aim to give an overview of current literature on the neuroprotective effects of apocynin in the prevention and treatment of neurodegenerative disorders. Particular attention is given to in vivo studies.
Several reports suggest that NADPH oxidase might also be implicated in other diseases such as Amyotrophic lateral sclerosis (ALS), Huntington’s disease (HD), epilepsy, HIV-associated dementia, schizophrenia, alcohol-induced neurodegeneration, and sleep disorders.
 

4.1.     Alzheimer

The neuroprotective effects of apocynin

There was a significant reduction in plaque load in the cortex and the hippocampus, and apocynin treatment also decreased the number of microglia in the cortex
 

4.2.    Parkinsonismus

– Oral treatment with the NADPH oxidase antagonist apocynin mitigates clinical and pathological features of parkinsonism in the MPTP marmoset model

In conclusion, compensation for the loss of DA and its metabolite HVA by apocynin mitigates the PD progression and limits the parkinsonian signs and motor-function deterioration.

– The neuroprotective effects of apocynin

Most importantly, apocynin is also beneficial when used in vivo in different animal models of PD; preadministration of apocynin protects against paraquat-induced dopaminergic cell death in mice (80) and 6-OHDA-induced neurodegeneration in rats
 

4.3.    Apoplex

The neuroprotective effects of apocynin
 

TCM

Die 5-Elementeanalyse bildet die Energiedynamik von Picrorrhiza wie folgt ab:

Zum Verständnis der Abkürzungen des Schaubildes siehe

Struktur – und Wandlungsmodell der chinesischen Medizin

http://www.chinesischemedizin.com/CMS/index.php/struktur-und-wandlungsmodell.html